Manchester Surgical Research Trust Manchester Surgical Research Trust
Welcome
Trustees
Research & Education Activities
Project News
Accounts
Vacancies
Contact Us
Professor Charles McCollum

Professor Charles McCollum


Professor of Surgery

Role

Head of the Academic Surgery Unit

Principle investigator in the following studies:

Founding chairman of the Vascular Governance North West ProgrammeChairman of the Steering Committee for a North West College of Academic Surgeons

Memberships

Association of Surgeons of Great Britain & Ireland
British Medical Association
European Society for Vascular and Endovascular Surgery
International College of Angiology
International Society of Cardiovascular Surgery
International Society of Thrombosis and Haemostasis
Surgical Infection Society (Charter Member)
Surgical Research Society of Great Britain  & Ireland
Vascular Surgical Society of Great Britain & Ireland
Member of UK National Screening Committee, Abdominal Aortic Aneurysms
Member, vCJD Committee on Blood Transfusion
Member, Working Party on alternatives to blood transfusion for the National Blood Service

Research

Professor McCollum’s research is in arterial and venous disease. He leads a research team of fellows, scientists and technicians, and his collaborations are with various disciplines including particularly epidemiology, neuro-imaging, mental health and stroke medicine. Research teams are assembled to investigate the role of cerebral emboli in dementia, migraine and dialysis-related brain injury.
Special research interests include:

Arterial Disease

Venous disease Other

Collaborators

Professor.Anthony Heagerty, Professor of Medicine and Head of Cardiovascular Sciences Research Group, University of Manchester
Dr.Simon Ray, Consultant Cardiologist and Clinical Director, Cardiology Department, Wythenshawe Hospital, Manchester
Dr.Brendan Davies, Consultant Neurologist, North Staffordshire Neurosciences Centre, Stoke on Trent
Dr.Charles Sherrington, Consultant Neurologist, Greater Manchester Neurosciences Centre, Hope Hospital, Manchester
Professor. Gary Macfarlane, Professor of Epidemiology, University of Aberdeen, Aberdeen
Dr.William Newman, Senior Lecturer and Consultant Clinical Genetist, University of Manchester
Mrs.Julie Morris, Head of Medical Statistics, Wythenshawe Hospital, Manchester
Dr.Paul Rolan, Professor of Pharmacology and Honorary Consultant Physician Headache Clinic, University of Adelaide, Australia
Prof Alistair Burns (Professor of Psychiatry)
Dr Sandip Mitra (Nephrologist Manchester Royal Infirmary)
Dr Nitin Purandare (Department of Psychiatry)
Prof Alan Jackson (Neuroradiology)
Dr Ismail Mohammed (Nephrology)
Dr Caroline Schiach, Consultant Haematologist
Dr Andrew Mortimer, Consultant Anaesthetist
Dr Oliver Hill, Consultant Anaesthestist
Mr Kay, Wrightington Hospital
Mr Kurdy, Department of Orthopaedics
Mr Walter, Emergency Medicine
Dr Dias and his team in the School of MaterialsKey Words

Methodological Knowledge

Complex vascular surgery
Multi-centre clinical trials
Population studies (cardiovascular epidemiology)
Autologous blood transfusion strategies
Investigation of cerebral perfusion

Teaching

I have been involved in both undergraduate and postgraduate education, having been trained in presentation skills, delivering lectures, and on interactive video link teaching including remote television teaching, my role is now that of a trainer. 

My commitment to undergraduate teaching remains a priority and includes one-to-one teaching in the outpatients, team teaching on the wards and formal lectures to undergraduates and postgraduates.  We strive to ensure that our trainees become fully involved in all aspects of our clinical practice, audit and research.  In vascular surgery we have regular clinical meetings and a postgraduate x-ray meeting with the vascular radiologists and trainees in both surgery and radiology.  The academic surgeons of the future need careful support in their approach to surgical training.  They need to be identified and introduced to research method at an early stage and to this end, I supervise higher degree research for surgeons, cardiologists and scientists:

I am now founding the North West College of Academic Surgery to offer the opportunity of a career in academic surgery to high flying undergraduates and to rejuvenate academic surgery in the North West.  I am joined in this venture by all the remaining surgical academics in Manchester and by approaching a dozen NHS colleagues who have demonstrated excellence in research or surgical education.  Members of this working party can boast a research grant income of £11.4 million since 2000.

Biography

Professor McCollum was appointed Professor of Surgery and Head of the Department of Surgery in the University of Manchester in 1989 and is an Honorary Consultant Surgeon at South Manchester University Hospital. The Academic Surgery Unit includes the Breast Unit which was developed to achieve an International reputation for research in surgical oncology now directed by Professor Nigel Bundred. Professor McCollum was previously trained in Birmingham and Leeds before being appointed Lecturer to Sir Geoffrey Slaney in Birmingham in 1978. He moved to London in 1983 as Senior Lecturer and subsequently Reader in Surgery in the University of London and Honorary Consultant Surgeon to Charing Cross Hospital. He is a Vascular Surgeon with a tertiary referral practice in carotid artery disease, cerebral perfusion, complex aneurysm surgery, including thoraco-abdominal aneurysm and in complex venous disease.

His initial research was on the role of intravascular emboli on the causation of pulmonary damage (shock lung) in surgical shock. He gained an international reputation for developing an Indium-labelled platelet technique for measuring thrombus growth in arterial disease and vascular prostheses leading to research contracts evaluating novel platelet inhibitory drugs. This early research led to the Moynihan Prize at the Association of Surgeons (UK), two Patey Prizes at the Surgical Research Society of Great Britain and the Hunterian Professorship at the Royal College of Surgeons of in 1985. His recent focus was to establish a cardiovascular epidemiology group in close collaboration with the Department of Public Health and Epidemiology in Manchester. It was research on paradoxical embolism as a cause of stroke in young adults that led to the hypothesis that multiple asymptomatic paradoxical micro-emboli over many years may be the cause of dementia. This led to a collaboration with Old Age Psychiatry leading to substantial funding from the Wellcome Trust and Alzheimer’s Society for research on cerebral emboli as a cause of dementia. Teams are now been assembled to explore the role of cerebral emboli in migraine and dialysis related cerebral injury.

Professor McCollum and his team continue to investigate which patients are at risk of venous insufficiency and venous ulceration.  This includes a retrospective cohort study comparing the frequency of venous insufficiency in patients undergoing hip and arm surgery and a study to investigate the frequency of DVT following sprain and conservatively managed ankle fracture.  He is also looking at a novel technique using ultrasound contrast to measure calf vein blood flow and measure the effects of standard compression stockings.  Professor McCollum is working to further develop a novel technology for the automated manufacture of bespoke compression hosiery.Professor McCollum has published over 380 papers including 264 on original research. Recent grant income includes project grant funding from the MRC, British Heart Foundation, Wellcome Trust, Alzheimer’s Society and Cancer Research Campaign in addition to grants from the manufactures of vascular grafts or devices, and the pharmaceutical industry. (Total £3.85 million since 2000).

Qualifications

MB, ChB (Birmingham) 1972
FRCS (London) 1976
FRCS (Edinburgh) 1976
MD (Birmingham)  1981
Certificate of Higher Surgical Training  1981

Selected Publications

2005

Brady AR, Gibbs JS, Greenhalgh RM, Powell JT, Sydes MR; POBBLE trial investigators
Peri-operative beta-blockade (POBBLE) for patients undergoing infra-renal vascular surgery: results of a randomised double-blind controlled trial
J Vasc Surg 2005; 41(4): 602-9

The EVAR Trial Participants
Endovascular aneurysm repair and outcome in patients unfit for open repair of abdominal aortic aneurysm (EVAR Trial II): randomised controlled trial
The Lancet 2005; 365 (9478): 2187-92

The EVAR Trial Participants
Endovascular aneurysm repair versus open repair in patients with abdominal aortic aneurysm (EVAR Trial I): randomised controlled trial.
The Lancet 2005; 365 (9478): 2179-86

Dix FP, Boyle S, McCollum CN
Mild and moderate varicose vein reflux does not deteriorate over time
Phlebology 2005; 20: 43-47

Dix FP, Reilly B, David MC, Simon D, Dowding E, Ivers L, Bhowmick A, McCollum CN.
Effect of leg elevation on healing, venous velocity and ambulatory venous pressure in venous ulceration
Phlebology 2005; 20: 87-94

Dix FP, Picton A, McCollum CN
Effect of superficial venous surgery on venous function in chronic venous insufficiency
Ann Vasc Surg 2005; 19: 678-685

Haynes SL, Bennett F, Torella F, McCollum CN
Does washing swabs increase the yield of salvageable red cells in aortic surgery?
Vox Sanguinis 2005;88:244-8

Purandare N, Welsh S, Burns A, Riding G, McCollum CN
Cerebral emboli and paradoxical embolisation in dementia: a pilot study.
Int J Geriatr Psychiatry 2005; 20: 12-16

McDowell G, Temple I, Li C, Kirwan CC, Bundred NJ, McCollum CN, Burton IE, Kumar S, Byrne GJ
Alteration in Platelet Function in Patients with Early Breast Cancer
Anticancer Research 2005; 25: 3963-66

Abd-el Aleem SA, Morgan C, Ferguson MW, McCollum CN, Ireland GW
Spatial distribution of mast cells in chronic venous leg ulcers
Eur J Histochem 2005; 49(3):265-72

Adam DJ, Beard JD, Cleveland T, Bell J, B, Bradbury AN, Forbes JF, Fowkes FG, Gillespie I, Ruckley CV, Raab G, Storkey H; The BASIL Trial Participants
Bypass versus angioplasty in severe ischaemia of the leg (BASIL) trail
The Lancet 2005; 366: 1925-34

2006
Sastry S, Riding G, Morris J, Taberner D, Cherry N, Heagerty A, McCollum CN
Young Adult Myocardial Infarction and Ischaemic Stroke: The role of paradoxical embolism and thrombophilia (The YAMIS study)
J Am Coll Cardiol 2006; 48(4):686-91

Bennett J, Haynes S, Torella F, Grainger H, McCollum CN
Acute normovolemic haemodilution in moderate blood loss surgery: a randomized controlled trial
Transfusion 2006, 46, 1097-1103

Purandare N, Daly KJ, Hardicre J, Morris J, Macfarlane G, Burns A, McCollum CN
Cerebral emboli as a potential cause of Alzheimer’s disease and vascular dementia: case-control study
BMJ 2006; 332:1119-24

Purandare N, Oude Vosharr RC, Davidson Y, Gibbons L, Hardicre J, Byrne J, McCollum CN, Jackson A, Burns A, Mann DMA
Deletion/Insertion polymorphism of the angiotensin-converting enzyme gene and white matter hyperintensities in dementia: a pilot study
J Am Geriatr Soc 2006; 54:1395-1400

Daly KJ, Ross ERS, Norris H, McCollum CN
Vascular complications of prosthetic inter-vertebral discs
Eur Spine J 2006;15:644-9. Epub http://dx.doi.org/10.1007/s00586-006-0166-0

Purandare N, Oude Voshaar RC, Burns A, Velupandian UM, McCollum CN
Paradoxical embolisation: a potential cause of cerebral damage in Alzheimer’s disease?
Neurol Res 2006;28:679-84

Purandare N, Oude Voshaar RC, Hardicre J, Byrne J, McCollum CN, Burns A
Cerebral emboli are associated with depressive symptoms in dementia
Br J Psychiatry 2006;189:260-3

Oude Voshaar RC, Purandare N, Hardicre J, McCollum CN, Burns A
Asymptomatic spontaneous cerebral emboli and cognitive decline in a cohort of older people: A prospective study
Int J Geriatr Psychiatry 2006:28;Epub

Patankar T, Widjaja E, Chant H, McCollum CN, Baldwin R, Jeffries S, Sutcliffe C, Burns A, Jackson A
Relationship of deep white matter hyperintensities and cerebral blood flow in severe carotid artery stenosis
Eur J Neurol 2006; 13; 10-16

Kirwan CC, McCollum CN, Bundred NJ, Byrne GJ
Current UK practice of thromboprophylaxis for breast surgery
Br J Surg 2006;93:1224-5

Seriki DM, Ashleigh RJ, Butterfield JS, England A, McCollum CN, Akhtar N, Welch M
Midterm follow-up of a single-center experience of endovascular repair of abdominal aortic aneurysms with use of the Talent stent-graft
J Vasc Interv Radiol 2006;17:973-7

Malde DJ, Abidia A, McCollum C, Welch M
The success of routine MRSA screening in vascular surgery: a nine year review
Int Angiol 2006;25:204-8

Henao EA, Hodge MD, Felkai DD, McCollum C, Noon GP, Lin PH, Lumsden AB, Bush RL
Contrast-enhanced Duplex surveillance after endovascular abdominal aortic aneurysm repair: improved efficacy using a continuous infusion technique
J Vasc Surg 2006;43:259-64

Greenhalgh RM, Brown LC, Powell JT, Thompson SG; EVAR Trial Participants.
Current interpretation of the UK EVAR Trials.
Acta Chir Belg. 2006;106:137-8

Daly KJ, Lovell M, McCollum CN
Are systemic emboli reduced in computer-assisted knee surgery?
J Bone Joint Surg Br 2006

Davies L, Brown TJ, Haynes S, Payne K, Elliott RA, McCollum C
Cost-effectiveness of cell salvage and alternative methods of minimising perioperative allogeneic blood transfusion: a systematic review and economic model (review)
Health Technol Assess 2006;10:iii-iv, ix-x, 1-210

2007
McCollum C N
Surgery for venous leg ulcers can reduce recurrence, but will have little impact on prevalence. BMJ 2007;335:55-56.

Patiar S, Kirwan CC, McDowell G, Bundred NJ, McCollum CN, Byrne GJ
Prevention of venous thromboembolism in surgical patients with breast cancer
Br J Surg 2007;94:412-20

Sastry K, Daly K, Chengodu T, McCollum C.
Is transcranial Doppler for the detection of venous-to-arterial circulation shunts reproducible?
Cerebrovasc Dis 2007;23:424-429

Daly KJ, Hutchinson S, McCollum CN
Can a peripheral artery be used to detect venous to arterial circulation shunts?
Cerebrovasc Dis 2007;25:111-114

Oude Voshaar RC, Purandare N, Hardicre J, McCollum C, Burns A
Asymptomatic spontaneous cerebral emboli and mood in a corhort of older people: a prospective study
Am J Geriatr Psych 2007;15:1057-1060

Purandare N, Voshaar RC, Morris J, Byrne JE, Wren J, Heller RF, McCollum CN
Asymptomatic spontaneous cerebral emboli predict cognitive and functional decline in dementia
Biol Psych 2007;62:339-44

Voshaar RC, Purandare N, Hardicre J, McCollum C, Burns A
Asymptomatice spontaneous cerebral emboli and cognitive decline in a cohort of older people: a prospective study
Int J Geriatr Psych 2007;22:794-800

Brown LC
Patient fitness and survival after abdominal aortic aneurysm repair in patients from the UK EVAR trials
BJS 2007;94:709-716

EVAR trial participants
Secondary interventions and mortality following endovascular aortic aneurysm repair: device-sepcific results from the UK EVAR trials
Eur J Vasc Endovasc Surg 2007;34:281-290

2008
Purandare N, Oude Voshaar RC, McCollum CN, Jackson A, Burns A
Paradoxical embolisation and cerebral white matter lesions in dementia
Br J Radiol 2008;81:30-4

Powell JT, Brown LC, Greenhalgh RM, Thompson SG; EVAR Trial Participants.
The rupture rate of large abdominal aortic aneurysms: is this modified by anatomical suitability for endovascular repair?
Ann Surg. 2008;247:173-9